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Each player tries to match the pips on one end of a tile from his hand with the pips on an open end of any tile in the layout. If a player is unable to match a tile from his hand with a tile in the layout, the player passes his turn to the player on his left. Each player may play only one tile per turn.

The first player to get rid of all dominoes announces "Domino!" and wins the game. If none of the players can make a play, the game ends in a block. If a game ends in a block, all the players turn the tiles in their hands faceup, count the pips on each tile, and add them together. The player with the lowest total wins the game and earns the points (1 point per pip) of all the tiles left remaining in his opponents' hands. The player who first reaches 100 points or more is the overall winner.